Aging involves several biological processes known as the "hallmarks of aging." Targeting these processes can help slow down and reverse skin aging. A new skin care serum (A+) was created using a special formula based on human fibroblast-conditioned media. This study explored how A+ works on four key aging mechanisms and tested its effectiveness for improving skin in people with moderate to severe facial sun damage.
Researchers conducted lab studies on skin samples and tested gene activity in 3D skin models. They also ran a 24-week clinical trial where participants used A+ or a placebo. Results were measured using surveys, skin biopsies, and visual assessments of skin improvement.
The serum A+ reduced markers of aging cells and boosted the activity of genes involved in cleaning out damaged proteins, maintaining cell health, and improving communication between skin cells. In the clinical trial, A+ significantly reduced sagging, wrinkles, sun damage, and uneven skin tone compared to the placebo. Participants reported looking younger, with an average self-perceived age reduction of six years after 12 weeks. Skin biopsies showed lower levels of aging markers and higher levels of collagen and elastin, which are important for firm, elastic skin.
This study demonstrated for the first time that a topical serum containing growth factors can address four major aging mechanisms—aging cells, loss of cell maintenance, reduced stem cell function, and poor cell communication. By targeting these processes, A? helps rejuvenate the skin, delivering quick and noticeable improvements.
Naughton, et al., Dermatol Ther (Heidelb) (2023) 13:169–186.
doi: 10.1007/s13555-022-00839-2.
© The Author(s) 2023.
