Adipose-derived stem cells (ADSCs) are easy to collect and have been shown to help protect skin from damage caused by UVB rays, which contribute to aging. Tiny particles called extracellular vesicles (EVs), released by these stem cells, can provide similar benefits without the safety concerns of using whole cells. These EVs, called ADSC-EVs, may have the potential to fight skin aging caused by UVB exposure, but their effectiveness is still unclear.
To test the effects of ADSC-EVs, researchers injected different amounts into mice with UVB-damaged skin once a week for 8 weeks. They assessed improvements in skin appearance and structure using various tests. In lab experiments, they treated skin cells called fibroblasts (FBs) with ADSC-EVs to see if they could reverse aging-related changes. They also looked at how the EVs reduced harmful molecules, improved antioxidant defenses, and decreased inflammation.
The study found that ADSC-EVs reduced wrinkles and promoted healthy skin cell growth in the UVB-damaged mice. They also decreased inflammation and harmful molecules that damage cells. In lab tests, ADSC-EVs protected fibroblasts from aging, improved their activity, and reduced inflammation and oxidative stress.
ADSC-EVs help fight skin aging by reducing harmful molecules and inflammation, which are major causes of skin damage and collagen breakdown.
Xu et al. Stem Cell Research & Therapy (2020) 11:264
https://doi.org/10.1186/s13287-020-01777-6
© The Author(s) 2020.
